Contribution to the Understanding of Desolvation Mechanisms: Impact of Crystal Size, Structural Purity and Process

Abstract
In the literature, the models and classifications devoted to the desolvation mechanisms often consider the incidence of structural features or the knowledge derived from kinetic studies, but have poorly recognised the impact of physical and macrocrystalline factors. Based on experimental studies and presumed mechanisms, it is shown here that crystal size, punctual or lattice defects, and structural purity may have a dramatic influence on the desolvation behaviour of organic and pharmaceutical crystals. As a consequence, the preparation route of each sample and the eventual physical treatments should be explicitly mentioned and taken into account for a satisfactory interpretation of experimental data.