Open Access
JEEP 2009
Article Number 00015
Number of page(s) 3
Published online 04 December 2009
JEEP 2009, 00015 (2009)
DOI: 10.1051/jeep/200900015

Advanced prototype using second harmonic generation (SHG) for pre-screening of conglomerates

A. Galland, V. Dureisseix, J. Mahieux, V. Dupray, H. Atmani and G. Coquerel

SMS UPRES EA3233, Université de Rouen La2B - Centre Universitaire d'Evreux, 1 rue du 7ème Chasseur- BP 281 F-27002 Evreux Cedex, France

Published online: 4 December 2009

Up to know, the enantiomers of component A (a chiral intermediate schematized in figure 1) have been separated by means of chiral chromatography. A less expensive method applicable to industrial production was requested. The resolution by preferential crystallization, which requires a stable conglomerate, could be one of the alternative routes. In this study, the screening of potential conglomerates was performed by using the Second Harmonic Generation (SHG). Among the 109 crystallization attempts with different counter ions and solvents, 51 crystalline salts were obtained; a single conglomerate-forming system has been detected (with sulfamic acid). Resolution by means of preferential crystallization has been achieved with this salt. This paper underlines the potential of SHG method as a pre high throughput technique for spotting chiral discrimination in the solid state.

Key words: Chiral discrimination -- Second Harmonic Generation -- stable conglomerate -- preferential crystallization

© Owned by the authors, published by EDP Sciences 2009