Open Access
Issue
JEEP 2009
2009
Article Number 00012
Number of page(s) 5
DOI https://doi.org/10.1051/jeep/200900012
Published online 04 December 2009
JEEP 2009, 00012 (2009)
DOI: 10.1051/jeep/200900012

Influence of solid/vapour equilibria on the stability of organic solids

N. Couvrat, Y. Cartigny and G. Coquerel

Laboratoire SMS - Unité de Croissance Cristalline et de Modélisation Moléculaire UPRES EA 3233, IRCOF - Université de Rouen-76921 Mont Saint Aignan Cedex

yohann.cartigny@univ-rouen.fr

Published online: 4 December 2009

Abstract
The influence of water (in its gaseous state) on the stability of crystallized organic compounds was investigated. Through two examples of solid/vapour equilibria, several behaviours were highlighted (stoichiometric or non stoichiometric hydrates, hydration/dehydration mechanisms, stability domains of multi-hydrates as a function of relative humidity). Phase diagrams (as a function of partial water pressure) and stability diagrams have been proposed for each example. This study illustrates that solid/vapour equilibrium knowledge is a crucial step during the complete characterization of solid organic compounds.


Key words: solid/vapour equilibrium -- pharmaceutical compounds -- hydration-dehydration


© Owned by the authors, published by EDP Sciences 2009