|Number of page(s)||5|
|Published online||04 December 2009|
Influence of solid/vapour equilibria on the stability of organic solidsN. Couvrat, Y. Cartigny and G. Coquerel
Laboratoire SMS - Unité de Croissance Cristalline et de Modélisation Moléculaire UPRES EA 3233, IRCOF - Université de Rouen-76921 Mont Saint Aignan Cedex
Published online: 4 December 2009
The influence of water (in its gaseous state) on the stability of crystallized organic compounds was investigated. Through two examples of solid/vapour equilibria, several behaviours were highlighted (stoichiometric or non stoichiometric hydrates, hydration/dehydration mechanisms, stability domains of multi-hydrates as a function of relative humidity). Phase diagrams (as a function of partial water pressure) and stability diagrams have been proposed for each example. This study illustrates that solid/vapour equilibrium knowledge is a crucial step during the complete characterization of solid organic compounds.
Key words: solid/vapour equilibrium -- pharmaceutical compounds -- hydration-dehydration
© Owned by the authors, published by EDP Sciences 2009