Free Access
| Issue |
J. Phys. IV France
Volume 11, Number PR10, Décembre 2001
Journées d'Étude des Équilibres entre Phases
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| Page(s) | Pr10-233 - Pr10-235 | |
| DOI | https://doi.org/10.1051/jp4:20011037 | |
Journées d'Étude des Équilibres entre Phases
J. Phys. IV France 11 (2001) Pr10-233-Pr10-235
DOI: 10.1051/jp4:20011037
1 Department of Peptide & Protein Chemistry, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain
2 Department of Physicochemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
© EDP Sciences 2001
J. Phys. IV France 11 (2001) Pr10-233-Pr10-235
DOI: 10.1051/jp4:20011037
Conformational study of HGV-NS3 (440-460) by circular dichroism (CD). Effect of lipophillic derivation on CD spectra
N. Rojo1, M.A. Alsina2 and I. Haro11 Department of Peptide & Protein Chemistry, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain
2 Department of Physicochemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain
Abstract
The present study was undertaken to examine the conformation by Circular Dichroism spectroscopy of the (440-460) : AIAYYRGKDSSIIKDGDLVVC peptide sequence belonging to the non-structural protein (NS3) of hepatitis G virus (HGV). The conformation of free HGV-NS3(440-460) and two lipophilic derivates at the N-terminus with palmitic and miristic acids respectively, was studied at different concentrations in HEPES as well as in the presence of the most commonly used agents for stabilizing conformations (TFE,HFIP).
© EDP Sciences 2001