Simplification of the landscape under high energy milling of molecular solids exhibiting polymorphism

Free access article

Issue		JEEP 2009 2009


Article Number		00013
Number of page(s)		4
DOI		http://dx.doi.org/10.1051/jeep/200900013
Published online		04 December 2009

JEEP 2009, 00013 (2009)
DOI: 10.1051/jeep/200900013

Simplification of the landscape under high energy milling of molecular solids exhibiting polymorphism

J. Linol and G. Coquerel

Unité de Croissance Cristalline et de Modélisation Moléculaire, SMS UPRES EA3233 –IRCOF, Université de Rouen F-76821 Mont Saint Aignan Cedex France

gerard.coquerel@univ-rouen.fr

Published online: 4 December 2009

Abstract
Polymorphism is of high occurrence among molecular solids quite often the number of polymorphs exceeds 3 – 4.Several studies have shown that under high energy milling if Tg < Tmilling there is a simplification of the landscape. That is to say for a given milling intensity, whatever the number of polymorphs existing without mechanical stress, a single polymorph corresponds to the steady state. By changing the milling intensity or the composition of the medium (wet milling for instance) a different variety might be accessible. This solid phase can be: the stable thermodynamic form, a metastable thermodynamic form, a dynamic new metastable form, a solvate, a co-crystal, etc. It is only under special conditions of intensity and composition that two polymorphs can co-exist as dual inter-converting steady states.

Key words: High Energy Milling -- polymorphism -- Steady State

© Owned by the authors, published by EDP Sciences 2009

What is OpenURL?

The OpenURL standard is a protocol for transmission of metadata describing the resource that you wish to access. An OpenURL link contains article metadata and directs it to the OpenURL server of your choice. The OpenURL server can provide access to the resource and also offer complementary services (specific search engine, export of references...). The OpenURL link can be generated by different means.

If your librarian has set up your subscription with an OpenURL resolver, OpenURL links appear automatically on the abstract pages.
You can define your own OpenURL resolver with your EDPS Account. In this case your choice will be given priority over that of your library.
You can use an add-on for your browser (Firefox or I.E.) to display OpenURL links on a page (see http://www.openly.com/openurlref/). You should disable this module if you wish to use the OpenURL server that you or your library have defined.